LaBioSignal – Biochemistry and Cell Signaling Laboratory

Here you will only find scientific productions directly related to LaBioSignal, designed, conducted and/or guided by the Laboratory coordinator

(Profa. Ariane).

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Zanchi M.M., Marins K., Zamoner A. Could pesticide exposure be implicated in the high incidence rates of depression, anxiety and suicide in farmers? A systematic review. Environ Pollut. 2023;331(Pt 2):121888. doi: 10.1016/j.envpol.2023.121888

De Oliveira V.S., Marins K., Mendes A.K.B., Zamoner A., Leite G.A.A., Silva F.R.M.B. In vivo exposure to pyriproxyfen causes ovarian oxidative stress and inhibits follicle maturation in zebrafish. J Appl Toxicol. 2023;43(6):799-807. doi: 10.1002/jat.4425

Zamoner A., Pereira M.L., Alves M.G. Toxicological and biochemical mechanisms of pesticides in non-targeted biological systems. Toxicol Appl Pharmacol. 2023;15;475:116648. doi: 10.1016/j.taap.2023.116648

Dos Santos D.C., Rafique J., Saba S., Grinevicius V.M.A.S., Filho D.W., Zamoner A., Braga A.L., Pedrosa R.C., Ourique F. IP-Se-06, a Selenylated Imidazo[1,2-a]pyridine, Modulates Intracellular Redox State and Causes Akt/mTOR/HIF-1α and MAPK Signaling Inhibition, Promoting Antiproliferative Effect and Apoptosis in Glioblastoma Cells. Oxid Med Cell Longev. 2022 Mar 22;2022:3710449. doi: 10.1155/2022/3710449

Rieg C.E.H., Cattani D., Naspolini N.F., Cenci V.H., de Liz Oliveira Cavalli V.L., Jacques A.V., Nascimento M.V.P.D.S., Dalmarco E.M., De Moraes A.C.R., Santos-Silva M.C., Silva F.R.M.B., Parisotto E.B., Zamoner A. Perinatal exposure to a glyphosate pesticide formulation induces offspring liver damage. Toxicol Appl Pharmacol. 2022;454:116245. doi: 10.1016/j.taap.2022.116245

Marafon F., Bonadiman B., de Rocco Donassolo S., Marins K., Zanchi M.M., Kosvosky G.C., Basso H.F., Zamoner A.,  Bagatini M.D. Deregulation of purinergic ectoenzyme activity in head and neck cancer promotes immunosuppression. Mol Biol Rep. 2022;49:7687–7695. https://doi.org/10.1007/s11033-022-07586-9

Karlsson O., Pierozan P., Cattani D., Zamoner A., Brittebo E. Developmental Exposure to a Glyphosate-Based Herbicide Induces Long-Term Impairments in the Melatonin Endocrine System and Oxidative Damage in the Striatum of Adult Rats. SSRN Electronic Journals: The English & Commonwealth Law Abstracts Journal. 2022. http://dx.doi.org/10.2139/ssrn.4051430

Naspolini N.F., Heinz Rieg C.E., Cenci V.H., Cattani D., Zamoner A. Paraquat induces redox imbalance and disrupts glutamate and energy metabolism in the hippocampus of prepubertal rats. Neurotoxicology. 2021;85:121-132. https://doi.org/10.1016/j.neuro.2021.05.010

Domingues ,J.T. Wajima C.S., Cesconetto P.A., Parisotto E.B., Winkelmann-Duarte E., Santos K.D., Saleh N., Filippin-Monteiro F.B., Razzera G., Regina Mena Barreto Silva F., Pessoa-Pureur R., Zamoner A. Experimentally-induced maternal hypothyroidism alters enzyme activities and the sensorimotor cortex of the offspring rats. Molecular and Cellular Endocrinology. 2018;478:62-76. https://doi.org/10.1016/j.mce.2018.07.008

Domingues J.T., Cattani D., Cesconetto P.A., Nascimento De Almeida B.A, Pierozan P., Dos Santos K., Razzera G., Regina Mena Barreto Silva F., Pessoa-Pureur R., Zamoner A. Reverse T-3 interacts with αvβ3 integrin receptor and restores enzyme activities in the hippocampus of hypothyroid developing rats: insight on signaling mechanisms. Molecular and Cellular Endocrinology. 2017;470:281-294. https://doi.org/10.1016/j.mce.2017.11.013

Cattani D., Cesconetto P.A., Tavares M.K., Parisoto E.B, Oliveira P.A., Rieg C.E.H, Leite M.C., Prediger R.D.S., Wendt N.C., Razzera G., Wilhelm-Filho D., Zamoner A. Developmental exposure to glyphosate-based herbicide and depressive-like behavior in adult offspring: implication of glutamate excitotoxicity and oxidative stress. Toxicology. 2017;387:67-80. https://doi.org/10.1016/j.tox.2017.06.001

Cesconetto P.A., Andrade C.M., Cattani D., Domingues J.T., Parisoto E.B., Wilhelm Filho D., Zamoner A. Maternal exposure to ethanol during pregnancy and lactation affects glutamatergic system and induces oxidative stress in offspring hippocampus. Alcoholism, Clinical and Experimental Research. 2016;40(1):52-61. https://doi.org/10.1111/acer.12917

Cattani D., De Liz Oliveira Cavalli V.L., Rieg C.E.H, Domingues J.T., Dal-Cim T., Tasca C.I., Regina Mena Barreto Silva F., Zamoner A. Mechanisms underlying the neurotoxicity induced by glyphosate-based herbicide in immature rat hippocampus: involvement of glutamate excitotoxicity. Toxicology (Amsterdam). 2014;320:34-45. https://doi.org/10.1016/j.tox.2014.03.001

De Liz Oliveira Cavalli V.L., Cattani D., Rieg C.E.H, Pierozan P., Zanatta L., Parisotto E.B, Wilhelm Filho D., Regina Mena Barreto Silva F., Pessoa-Pureur R., Zamoner, A. Roundup disrupted male reproductive functions by triggering calcium-mediated cell death in rat testis and sertoli cells. Free Radical Biology & Medicine. 2013;65:335-346. https://doi.org/10.1016/j.freeradbiomed.2013.06.043

Cattani D., Goulart P.B., De Liz Oliveira Cavalli V.L., Winkelmann-Duarte E., Dos Santos A.Q., Pierozan P., De Souza D.F., Woehl V.M., Fernandes M.C., Regina Mena Barreto Silva F, Gonçalves C.A., Pessoa-Pureur R., Zamoner A. Congenital hypothyroidism alters the oxidative status, enzyme activities and morphological parameters in the hippocampus of developing rats. Molecular and Cellular Endocrinology. 2013; 375(1-2):14-26. https://doi.org/10.1016/j.mce.2013.05.001

Parisotto E.B., Silva N.G.M., Wajima C.S., Rahn B., Domingues J.T., Cenci V.H., Cesconetto P.A., Cattani D., Rieg C.E.H., Hellbrugge A., Felipe K.B., Pedrosa R.C. Zamoner A. Effects of paraquat in the reproductive function and on redox state of adult male rats. Free Radical Biology and Medicine. 2018;120:S88-S89. https://doi.org/10.1002/jbt.21870